Description: Large lizard that has it's head split open. The only way to do damage to it is to shoot it's open mouth. It will instantly kill Harry if it bites him.
Difficulty: Medium
Recommended weapon: Shotgun
Location: Basement of the alternate school
Twinfeeler
Description: Giant larva, which burrows under the sand a comes up in random areas, and releases poisonous venom in the air. This is a fairly easy boss that does little damage.
Difficulty: Easy
Recommended weapon: Shotgun
Location: Silent Hill shopping mall
Floatstinger
Description: Giant moth, which is the full grown version of the twinfeeler. It flies in the air and using it's giant stinger and by releasing poisonous venom.
Difficulty: Medium
Recommended weapon: Rifle or shotgun
Location: Rooftop across from the hospital
Cybil
Description: A possessed version of Cybil. You can either fight her (resulting in her death and the good or bad ending) or use the red liquid on her (resulting in her being saved and the good+ or bad+ endings). She attack by shooting her gun, which does a lot of damage, and by hitting Harry with the gun.
Difficulty: Very easy/hard
Recommended weapon: Rifle or red liquid
Location: Amusement park
The God
Description: In this fight you will either fight the incubator (Alessa) or the incubus (the creature that is expelled from Alessa if Kaufmann is saved), depending on whether or not you saved Kaufmann earlier in the game. They are both pretty much the same except the incubus can fly. They do damage by striking Harry with lightning. In the Hard difficulty this will instantly kill Harry so you must use a health item as soon as he first get struck by lightning. The best way to do this fight is to empty all your guns and have no ammo when the fight starts. Don't do anything and the god will automatically die after a few moments. NOTE: This does not work if you have the hyper blaster.
Difficulty: Very easy/very hard
Recommended weapon: None or the rifle
Location: End of Nowhere, past Alessa's bedroom